Return to Article Details KARAKTERISASI EKSTRAK KASAR FITASE TERMOFILIK DARI BAKTERI KAWAH IJEN BANYUWANGI, ISOLAT AP-17 Download Download PDF

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    <depositor>
      <depositor_name>Wulida Khoirunnisa</depositor_name>
      <email_address>wulidanisa5518@gmail.com</email_address>
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    <registrant>The East Java Biological Society</registrant>
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        <full_title>Berkala Penelitian Hayati</full_title>
        <abbrev_title>Berkala Penelitian Hayati</abbrev_title>
        <issn media_type="electronic">2337-389X</issn>
        <issn media_type="print">0852-6834</issn>
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        <publication_date media_type="online">
          <month>01</month>
          <day>25</day>
          <year>2025</year>
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          <volume>31</volume>
        </journal_volume>
        <issue>1</issue>
        <doi_data>
          <doi>10.23869/bphjbr.31.1</doi>
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        <titles>
          <title>Effect of Spatholobus littoralis hassk extract on matrix metalloproteinase-1 and elastin fiber morphology in d-galactose-ınduced aging model rats</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first">
            <given_name>Luh Ade Lela</given_name>
            <surname>Arika</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <surname>Harliansyah</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Puput Putuh </given_name>
            <surname>Anisa</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional">
            <given_name>Nenden Lilis </given_name>
            <surname>Setiasih</surname>
          </person_name>
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          <jats:p>This study was investigates the effects of ethanol extract of bajakah wood (Spatholobus littoralis Hassk) on skin aging with D-galactose-induced Sprague-Dawley rats, focusing on Matrix Metalloproteinase-1 (MMP-1) concentration and elastin fiber morphology. A total of 36 male rats were divided into six groups; I (Blank), II, III, IV, V and VI, receiving varying doses of the extract. MMP-1 levels were measured using an ELISA kit, while elastin fibers were assessed through Verhoeff Van Gieson staining. The results show that the extract indicated that the extract significantly inhibit MMP-1 activity, with group 2 exhibiting the highest concentration (35.78 ng/ml) compared to other groups (p = 0.039). Furthermore, the extract notably increased elastin fiber content, particularly in group 6 (100 mg/kgBB), which showed a mean percentage of 7.10% compared to 2.22% in the control group (p &lt; 0.001). Qualitative analysis revealed a more intense and evenly distributed brown coloration in higher-dose treatment groups, indicating enhanced elastin density. These findings suggest that bajakah wood extract possesses antioxidant and anti-inflammatory properties, making it a promising candidate for therapeutic interventions aimed at improving skin quality and combating age-related changes. By modulating MMP-1 activity and promoting elastin synthesis, the extract could serve as a valuable addition to skincare formulations. Future research should explore the specific mechanisms through which bajakah wood extract exerts its effects, as well as its long-term efficacy and safety in human applications, to fully realize its therapeutic potential.</jats:p>
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        <publication_date media_type="online">
          <month>04</month>
          <day>12</day>
          <year>2025</year>
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        <pages>
          <first_page>66</first_page>
          <last_page>70</last_page>
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          <doi>10.23869/bphjbr.31.1.202510</doi>
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