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Erna Yovi Kurniawati Noor Pramono Syarief Thaufik Hidayat Endang Mahati

Abstract

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women that is characterized by hormonal imbalances, anovulation, and ovarian cysts. Folliculogenesis, which is the process of follicle development, is perturbed in PCOS, leading to irregular menstrual cycles and fertility issues. Clitoria ternatea, a medicinal plant with potential hormonal regulatory properties, is of interest for exploring its effects on folliculogenesis and PCOS management. In this in silico study, we employed molecular docking techniques to investigate the interaction between bioactive compounds from Clitoria ternatea and Follicle-Stimulating Hormone Receptor (FSHR), a key regulator of folliculogenesis. AutoDock Vina and PyRx software were used to predict the binding affinities and interactions between the ligands and FSHR. The results of our in-silico study indicate that bioactive compounds from Clitoria ternatea exhibit a strong binding affinity for FSHR. These compounds form stable interactions with the receptor, suggesting a potential regulatory effect on FSHR activity during folliculogenesis. The findings from this in silico study suggest that Clitoria ternatea may play a role in modulating folliculogenesis by interacting with FSHR. Further experimental studies, including in vitro and in vivo studies, are warranted to validate these computational predictions and explore the potential therapeutic implications of Clitoria ternatea in managing PCOS-related folliculogenesis disorders.

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Keywords

Clitoria ternatea, folliculogenesis, FSHR, PCOS

References
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How to Cite
Kurniawati, E. Y., Pramono, N., Hidayat, S. T., & Mahati, E. (2024). Effect of Clitoria ternatea on follicle stimulating hormone receptor: Molecular docking study. Berkala Penelitian Hayati, 30(1), 29-34. Retrieved from https://berkalahayati.org/index.php/jurnal/article/view/755
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