Najma Zahira Nia Kurnianingsih Nia Kurniwan


Ophiophagus hannah has significant medical important among snakebite cases. The enzyme Phospholipase A2 (PLA2) is crucial for venom impacts in life-threatening symptoms. However, specific antivenom against this species remains underexplored. This study aimed to analyze the potential of  secondary metabolites from tamarind as PLA2 protein inhibitor specifically from Ophiophagus hannah venom using in-silico approaches. The sequences and three-dimensional structure of the PLA2 protein from O. hannah were physicochemicaly predicted using ProtParam. Virtual screening, drug-likeness, pharmacokinetic, and toxicity profiles of metabolite compound from Tamarind was performed using SwissADME. All ligands were downloaded from PubChem database. Molecular docking was carried out using PyRx and visualized using Discovery Studio 2016 software. All tamarind’s compounds are safe for long term administration because they displayed minimum risk for hepatotoxicity and AMES. The best interaction of secondary metabolites with PLA2 is owned by quercetin. Future in-vitro and in-vivo studies are needed to evaluate the use of secondary metabolite compounds as specific alternatives of antivenoms.

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King cobra, phospholipase A2, secondary metabolite, Tamarindus indica.

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Zahira, N., Kurnianingsih, N., & Kurniwan, N. (2024). The virtual antivenom prediction of tamarind compounds as inhibitor against Ophiophagus hannah phospholipase A2. Berkala Penelitian Hayati, 30(1), 21-28. Retrieved from https://berkalahayati.org/index.php/jurnal/article/view/769